Clinical Scientist

Great Ormond Street Hospital for Children NHS Foundation Trust

Applications are invited from State Registered Clinical Scientists in Genomics; scientists close to registration will also be considered.The scientist will be joining the team at the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital. We are seeking enthusiastic, self-motivated scientists with experience of genomic service delivery and a sound understanding of molecular and cytogenetic techniques and analysis. Accomplished communication and organisational skills are required.The successful candidate will join the postnatal team at the North Thames Rare Disease Laboratory Hub at Great Ormond Street Hospital. Experience of cytogenetic analysis and interpretation including karyotyping and copy number analysis is essential.We support trained scientists who wish to adopt flexible and/or hybrid working patterns. For Clinical Scientists, after a successful probation period, there is a requirement to work on-site for 40% of working hours.Main duties of the job

The Rare Disease Laboratory has an establishment of approximately 160 including technologists, clinical scientists, translational scientists, bioinformaticians and administrative support staff. Along with two Clinical Genetics teams we form a strategic Genetics Unit within the hospital and provide North London with a Regional Genetics Service serving a population of approximately 10 million. Having been awarded 11 specialisms in the NHSE Genomic Medicine Service, the laboratory provides an in-house diagnostic service for cancer, molecular and cytogenetic testing in accordance with the NHS England Genomic Test Directory. Cytogenetic testing is provided for both prenatal and postnatal samples using SNP microarray, karyotyping, FISH, and qPCR. Molecular testing includes next generation sequencing and targeted tests. We are also engaged in the delivery of the NHSE GMS Whole Genome Sequencing programme for our North Thames patients.We are involved in a number of collaborative research and development projects with colleagues at the UCL Institute of Child Health and Institute of Neurology as part of the UCL Partners Academic Health Sciences Centre. We provide a DNA preparation and storage service in support of many of these projects.Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below.Person Specification

BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experienceHCPC Clinical Scientist Registration CertificateExperience/Knowledge

Experience working in a clinical diagnostics/genomics laboratoryExtensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic serviceExperience of writing clinical genetics reportsKnowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing dataTrack record of scientific Publications/ presentationsExperience in the analysis and reporting of whole genome sequencing dataEvidence of supervising/training other staffExperience with laboratory information and quality management systemsSkills/Abilities

Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / MicroarrayGood organisational and interpersonal skills. Willing to adapt to changes in workflow and organisationComputer literate, including use of Genetic databases, analytical software, variant classificationAble to communicate effectively both verbally and in writing (by email and by appropriate documentation)Able to write protocolsBackground in cytogenetic and molecular proceduresDisclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.Salary and Contract Details

£54,320 to £60,981 a year per annum inclusivePermanentFull-timeReference number

271-GEN-7120178Job locations

Great Ormond Street Hospital for Children NHS Foundation ..... full job details .....