Senior / Principal Scientist

Help drive the TCR engineering processes and development by leading in vivo and in vitro validation of TCEs. You''ll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.Client DetailsThe client are reimagining what''s possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies.DescriptionLead in vivo and in vitro validation of TCEs.Collaboratively design and characterise TCRs for proprietary and partnered disease targets.Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation. Join forces with founders, RandD, academia, and industrial stakeholders to fulfil ambitious RandD objectives.Draft, revise, and oversee repertoire of lab protocols.Offer essential lab support and uphold facility upkeepProfile PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.For senior scientist we are looking for over 3 years industry experience.Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to ..... full job details .....