Principal Scientist

About the RoleWe are seeking an experienced Principal Scientist, Non-Clinical PKPD to join the Early Clinical Development and Translational Sciences Department. You will play a key role in shaping the quantitative integrated strategy of pharmacokinetics and pharmacology (PKPD, systems modelling, clinical pharmacology/pharmacometrics) across the lifecycle of projects — from target identification through to life cycle management.

Key Responsibilities

Lead the non-clinical PKPD strategy and support the design of study protocols, including GLP toxicokinetic studies.

Analyse, interpret, and report PKPD results in collaboration with internal teams (Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and CRO partners.

Deliver high-quality PKPD data packages that meet regulatory standards, including study reports and integrated summaries.

Communicate results effectively to diverse stakeholders and contribute to regulatory submission documents.

Advance drug candidates by developing deep knowledge of their pharmacology and PKPD profiles.

Represent the department internally and externally, contributing to UCB’s scientific reputation.

Skills and Experience

PhD/MSc/BSc in a relevant discipline (quantitative pharmacology, PK/PD, DMPK, etc.) with 5+ years’ hands-on PKPD analysis experience in pharma or CRO.

Strong understanding of disease and drug mechanisms, with proven experience in designing and executing non-clinical PKPD studies.

Proficiency in Phoenix WinNonlin (essential). Experience with tools such as Berkeley Madonna and/or R is advantageous.

Experience in GLP toxicokinetic analysis, data interpretation, and reporting.

Ability to manage multiple projects simultaneously, with excellent written and verbal communication skills.

Track record of high-quality regulatory submissions; publications in PKPD are a plus.

Screening for this role will take place within the next

24 hours . If you have the right skills and experience, please apply immediately to be considered. Consider sending your CV to the email address: ..... full job details .....