Clinical Research Fellow

Overview

Clinical Research Fellow – UCL/UCLH Institute of Neurology, Ataxia Centre. Applications are invited for a Clinical Research Fellow in the Ataxia Centre, UCL/UCLH Department of Neuroscience and Neurogenetics, UCL Institute of Neurology, under the supervision of Prof Paola Giunti. The post offers an opportunity to gain experience of translational research as part of an internationally recognised multi-disciplinary team. The postholder will be an essential member of the research team at the Ataxia Centre, providing clinical and research input into the Centre’s research programme into Ataxia.The successful candidate will work closely with the Principal Investigators (PIs), Clinical Research Fellows and Clinical Trials nurses. Their primary role will be as sub-investigator in a clinical drug trial: a phase 1/2a, open-label trial to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of intrathecally administered VO659 in participants with spinocerebellar ataxia types 1, 3, assessing the safety of this novel antisense oligonucleotide (ASO) treatment in patients with these rare diseases. They will also have the opportunity to participate in current basic and observational research including longitudinal studies of dominant and recessive ataxias and at-risk groups and healthy volunteers to identify reliable biomarkers of disease and develop new therapeutic targets.Applicants should have a medical degree and full GMC Registration, and have previous experience in neurology, or general medicine and excellent skill in performing lumbar puncture. The successful candidate will have good inter-personal skills, the ability to work co-operatively in a multidisciplinary setting and the ability to demonstrate a record of academic clinical excellence.Responsibilities

Serve as sub-investigator in a phase 1/2a open-label clinical trial of VO659 in spinocerebellar ataxia types 1 and 3, including oversight of safety, tolerability, pharmacokinetics, and pharmacodynamics.Provide clinical input to the Ataxia Centre research programme and work with PIs, Clinical Research Fellows and Clinical Trials nurses.Participate in current basic and observational research, including longitudinal studies and biomarker identification to inform new therapeutic targets.Collaborate in multidisciplinary clinical and research activities within the Centre and Institute.Qualifications

Medical degree and full GMC Registration.Experience in neurology or general medicine.Excellent skill in performing lumbar puncture.Strong interpersonal skills and ability to work in a multidisciplinary setting.Demonstrated record of academic clinical excellence.Benefits

Interest-free season ticket loan for travel (permanent staff).Subsidised social club including gym, staff library, and access to on-site accommodation.Free independent and confidential support for all staff and staff discounts.Car leasing scheme among other benefits.How to apply / Contact

For further details or informal visits contact: Samantha Robinson, Personnel Officer, Email: ion.hradmin@ucl.ac.uk. Informal enquiries are welcome to Prof Paola Giunti: 0203 448 4018 or p.giunti@ucl.ac.uk. Address: UCL Institute of Neurology, 23 Queen Square, London, WC1N ..... full job details .....